SOX9 Duplication Linked to Intersex in Deer

R Kropatsch; G Dekomien; DA Akkad; WM Gerding; E Petrasch-Parwez; ND Young; J Altmüller; P Nürnberg; RB Gasser; JT Epplen

Journal article

SOX9 Duplication Linked to Intersex in Deer

R Kropatsch, G Dekomien, DA Akkad, WM Gerding, E Petrasch-Parwez, ND Young, J Altmüller, P Nürnberg, RB Gasser, JT Epplen

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013

DOI: 10.1371/journal.pone.0073734

Download PDF

Abstract

A complex network of genes determines sex in mammals. Here, we studied a European roe deer with an intersex phenotype that was consistent with a XY genotype with incomplete male-determination. Whole genome sequencing and quantitative real-time PCR analyses revealed a triple dose of the SOX9 gene, allowing insights into a new genetic defect in a wild animal. © 2013 Kropatsch et al.

University of Melbourne Researchers

Neil Young Author

Robin B. Gasser Author

Related Projects (2)

Discovering the function and structure of RIO kinases - toward new nematocides

This project is focused on: high quality fundamental molecular science, contributing to national objectives, including the development of no..

HARNESSING THE GENOMICS REVOLUTION - TOWARD RADICALLY NEW APPROACHES TO CONTROL NEGLECTED PARASITES OF PARAMOUNT GLOBAL IMPORTANCE

Frontier technologies will be used to unlock the molecular secrets of neglected parasites causing devastating diseases in animals and humans..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

RBG's research is funded by the Australian Research Council (ARC, LP110100018, http://www.arc.gov.au/), the National Health and Medical Research Council (NHMRC, APP1044022, http://www.nhmrc.gov.au/), Melbourne Water Corporation (http://www.melbournewater.com.au/), and the Alexander von Humboldt Foundation (http://www.humboldt-foundation.de/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.